ISO INTERNATIONAL STANDARD 18664 Firstedition 2015-08-01 TraditionalChineseMedicine- Determinationofheavymetalsin herbal medicines used in Traditional Chinese Medicine Medecine traditionnelle chinoiseDosagedes metaux lourdsdans les herbes medicinales utilisees dans la medecine traditionnelle chinoise Referencenumber IS018664:2015(E) ISo ISO2015 956617 No leproductinornenworkingperimitled without licenee trom Hs IS018664:2015(E) COPYRIGHTPROTECTEDDOCUMENT IS02015,Published in Switzerland All rights reserved.Unless otherwise specified, no part of this publication may be reproduced orutilizedotherwise in anyform or by any means, electronic ormechanical, including photocopying,or posting on the internet or an intranet,without prior therequester. IsO.copyrightoffice Ch.deBlandonnet 8-CP 401 CH-1214 Vernier, Geneva, Switzerland Tel+41227490111 Fax+41227490947 copyright@iso.org www.iso.org anizatlorifor Standardization Nowokingewio NotforPesale,2015/10/2207:25:32 IS018664:2015(E) Contents Page Foreword iv Introduction 1 Scope .1 2 Normativereferences 1 3 Terms and definitions 2 4 Analytical methods 2 4.1 Instrumentalmethods 2 4.1.1 AtomicAbsorptionSpectrometry(AAS) 2 4.1.2 Inductively-CoupledPlasma-AtomicEmissionSpectrometry(ICP-AES) 3 4.1.3 Inductively-CoupledPlasmaMassSpectrometry (ICP-MS) 3 4.2 Comparisonofinstrumentalmethods. .3 Annex A (informative) Reference of national, regional and organizational limits of heavy metals in natural TCM materials and calculated limits using Target Hazard QuotientsbasedonUSEPAandWHo .5 Bibliography 8 ii 956617 Nnwi NotforPesale,2015/10/2207:25:32