ISO INTERNATIONAL STANDARD 11843-5 First edition 2008-06-01 Capability of detection - Part 5: Methodology in the linear and non-linear calibration cases Capacité de détection- Partie 5: Methodologie des étalonnages lineaire et non lineaire Reference number ISO 11843-5:2008(E) @ ISO 2008 py IHS under lic itted without license from IHS Not for Resale ISO 11843-5:2008(E) PDF disclaimer This PDF file may contain embedded typefaces. In accordance with Adobe's licensing policy, this file may be printed or viewed but shall not be edited unless the typefaces which are embedded are licensed to and installed on the computer performing the editing. In downloading this file, parties accept therein the responsibility of not infringing Adobe's licensing policy. The IsO Central Secretariat accepts no liability in this area. Adobe is a trademark of Adobe Systems Incorporated. Details of the software products used to create this PDF file can be found in the General Info relative to the file; the PDF-creation parameters were optimized for printing. Every care has been taken to ensure that the file is suitable for use by IsO member bodies. In the unlikely event that a problem relating to it is found, please inform the Central Secretariat at the address given below. COPYRIGHT PROTECTED DOCUMENT @ ISO2008 All rights reserved. Unless otherwise specified, no part of this publication may be reproduced or utilized in any form or by any means, IsO's member body in the country of the requester. ISO copyright office Case postale 56 . CH-1211 Geneva 20 Tel. + 41 22 749 01 11 Fax + 41 22 749 09 47 E-mail [email protected] Web www.iso.org Published in Switzerland @ IS0 2008 - All rights reserved py IHS unde I without license from IHS Not for Resale ISO 11843-5:2008(E) Contents Page Foreword. Introduction 1 Scope 2 Normative references . 3 Terms and definitions 4 Precision profile of the net state variable ... 5 Critical value and minimum detectable value of the net state variable 5.1 General.. 5.2 Calculation relating to probability α 5.3 Calculation relating to probability ... 5.4 Differential method . 6 Examples 6.1 6.2 Law of propagation of uncertainty. 6.3 Model fitting.... 6.4 Application to competitive ELISA Annex A (normative) Symbols and abbreviations used in this part of Iso 11843 12 Annex B (informative) Derivation of Equation (9) ... 13 Annex C (informative) Derivation of Equation (13) .. 14 Bibliography 5 Copyright International Organization for Standardizalon ghts reserved ili nse from IHS Not for Resale